Table 3.
Clinical characteristics of falciparum malaria patients with pathogens detected on blood culture
| Patient | Study | Age/gender | Parasite count* | RCAM score† | Leukocytes (×109/L) | Neutrophils (×109/L) | Comorbidities | Bacterial coinfection suspected clinically | Blood pressure on admission (MAP mm of Hg) | Organism(s) identified in blood culture | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Multicenter | 26, male | NR | 4 | 12.8 | 9.4 | No | No | 120/80 (93) | Staphylococcus aureus‡ | Survived |
| 2 | Multicenter | 32, male | NR | 4 | 6.6 | 4.9 | HIV | Yes | 100/80 (87) | Salmonella typhi | Survived |
| 3 | Multicenter | 42, male | NR | 4 | 10.8 | 8 | No | No | 80/50 (60) | Salmonella typhimurium | Survived |
| 4 | Multicenter | 36, female | NR | 3 | 6.5 | 4.2 | No | No | 90/50 (63) | Escherichia coli | Survived |
| 5 | Multicenter | 52, male | NR | 4 | 8.6 | 7.9 | No | No | 130/90 (103) | Salmonella paratyphi | Survived |
| 6 | ANTHEM | 35, male | 1+ | 2 | 12 | 8 | Cirrhosis | No | 80/50 (60) | E. coli | Died day 12 of admission |
| 7 | ANTHEM | 77, male | 1+ | 2 | 25 | 18 | Cirrhosis, atrial fibrillation and congestive cardiac failure | Yes | 80/60 (67) | Acinetobacter baumannii§ Enterobacter cloacae | Died day 11 of admission |
| 8 | Multicenter | 20, male | 1+ | 2 | 8.4 | 6.5 | No | No | 90/60 (70) | E. coli‖ | Survived |
| 9 | ANTHEM | 19, male | 1+ | 2 | 5.6 | 2 | No | Yes | 100/70 (83) | S. typhi | Survived |
| 10 | Multicenter | 23, male | NR | 1 | 7.3 | 6.5 | No | No | 110/80 (90) | S. paratyphi | Survived |
| 11 | ANTHEM | 39, male | 1+ | 1 | 9.9 | 4.5 | No | No | 110/80 (90) | S. aureus | Survived |
| 12 | Multicenter | 19, female | NR | 1 | 12.8 | 9.8 | No | Yes | 100/70 (83) | S. aureus | Survived |
| 13 | Multicenter | 50, male | NR | 1 | 10.4 | 8 | Diabetes mellitus | Yes | 140/100 (113) | E. coli‖ | Survived |
ANTHEM = antibiotic therapy in adults with malaria; MAP = mean arterial pressure; NR = not recorded. Clinical and laboratory findings recorded at presentation.
Parasite counts recorded semiquantitatively (1+ to 4+). Note that only 17 of the 67 patients in the multicenter study were able to have a semiquantitative parasite count recorded. All patients in the multicenter study had a positive qualitative blood film.
Calculated using respiratory rate and Glasgow coma scale.12
Community-acquired methicillin-resistant S. aureus.
Intrinsically resistant organism, but this isolate was sensitive to cefepime and carbapenems.
Extended spectrum β-lactamase producer.