Table 2.
Frequencies of micronucleated polychromatic erythrocytes (MNPCEs) and PCE/PCE+NCE ratio in Swiss mouse bone marrow treated with VdE and/or MMS and their respective controls.
|
Treatment (mg/kg b.w.) |
MNPCEs a, c | PCE/PCE + NCE a, b |
|---|---|---|
| Control | 6.33 ± 1.75 | 0.63 ± 0.13 |
| DMSO | 6.33 ± 2.34 | 0.63 ± 0.08 |
| 500 | 4.33 ± 1.96 | 0,.66 ± 0.09 |
| 1000 | 4.16 ± 1.47 | 0.72 ± 0.08 |
| 2000 | 7.83 ± 2.78 | 0.60 ± 0.05 |
| MMS | 41.50 ± 9.13 d | 0.61 ± 0.10 |
| DMSO + MMS | 48.00 ± 9.40 d | 0.61 ± 0.06 |
| 15 + MMS | 22.83 ± 2.48 d, e | 0.63 ± 0.05 |
| 30 + MMS | 42.60 ± 6.43 d | 0.55 ± 0.12 |
| 60 + MMS | 47.00 ± 5.17 d | 0.62 ± 0.05 |
VdE: ethanolic extract of Vochysia divergens leaves; PCE: polychromatic erythrocytes; NCE: normochromatic erythrocytes; DMSO: dimethyl sulfoxide (5%); MMS: methyl methanesulfonate (40 mg/kg b.w.). aValues are the mean ± standard deviation. bA total of 400 erythrocytes were analyzed per animal, corresponding to 2,400 cells per treatment. cA total of 2,000 PCEs were analyzed per animal, corresponding to 12,000 cells per treatment. dSignificantly different from control (P < 0.05). eSignificantly different from the MMS group (P < 0.05).