Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Sep 26;9:1087. doi: 10.3389/fphar.2018.01087

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Wang, Chen, Liu, Liu, Luo, Chen, Deng, Luo, He, Zhang, Hill, Li and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Genetic deletion and pharmacological inhibition of PAI-1 improves glucose tolerance and insulin sensitivity. (A,B) Glucose tolerance tests (GTT) and AUC in each group. N = 6 per group. *P < 0.05 vs. ND-WT; **P < 0.05 vs. ND-WT; ^#P < 0.05 vs. HFD-WT vehicle. HFD was associated with elevated fasting glucose levels and impaired glucose tolerance. PA1-1 depletion or inhibition (C,D) Insulin tolerance tests (ITT) and AUC in each group. N = 6 per group. *P < 0.05 vs. ND-WT; **P < 0.05 vs. ND-WT; ^#P < 0.05 vs. HFD-WT.