Table 1.
Plasma lipid characteristics.
| ND-WT | ND-Pai-1−/− | HFD-WT | HFD-Pai-1−/− | HFD-WT + PAI-039 | |
|---|---|---|---|---|---|
| TC | 1.91 ± 0.12 | 1.44 ± 0.21* | 2.86 ± 0.09 | 1.31 ± 0.30# | 1.72 ± 0.43# |
| TG | 0.27 ± 0.08 | 0.26 ± 0.05 | 0.34 ± 0.02 | 0.26 ± 0.05# | 0.30 ± 0.02# |
| LDL-C | 0.4 ± 0.03 | 0.45 ± 0.05 | 0.68 ± 0.08 | 1.23 ± 0.14# | 0.39 ± 0.06# |
| HDL-C | 1.13 ± 0.11 | 0.85 ± 0.12* | 1.63 ± 0.08 | 0.98 ± 0.08# | 1.17 ± 0.26# |
All units are mM. Values are mean ± SEM.
*
p < 0.05 vs. WT mice receiving normal diet;
#
p < 0.05 vs. WT fed western diet; n = 3 mice per group. TC, total cholesterol; TG, triglycerides; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; WT, wild-type.