One way ANOVA analysis of grey matter volume among three groups. A, brain area showing significant difference in grey matter volume among three groups (Red). B, Compared with healthy controls, MHE group exhibited decreased grey matter volume in bilateral caudatum and globus pallidus, left hippocampus, and cerebellar vermis (Blue). Significant increased grey matter volume was also observed in bilateral thalamus and the calcarine cortex (Red). C, Similar findings also showed in No-HE group, but the areas showing significance was confined.