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Comparison of approaches that distinguish deleterious and neutral amino acid substitutions. The fraction of true positives (sensitivity) vs. the fraction of true negatives (specificity) is shown for seven approaches (LRTm is a masked version of LRT, PPH2 is PolyPhen2). The curves are based on 2,910 deleterious variants and 1,583 neutral variants. Vertical and horizontal dashed lines show the cutoff at 95% specificity and 95% sensitivity, respectively.
