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Model for the activity of FcRn as an IgG homeostat.
IgG enters cells by fluid-phase pinocytosis in small tubulovesicular transport carriers that fuse with larger, FcRn-positive early (sorting), acidic endosomes in which binding to FcRn can occur. Bound IgG molecules are recycled and released by exocytosis involving fusion of recycling compartments with the plasma membrane. By contrast, IgG that does not bind to FcRn in sorting endosomes enters lysosomes and is degraded.
