Table 2.
A/PR |
A/Victoria |
B/Lee |
B/Maryland |
||||||
---|---|---|---|---|---|---|---|---|---|
CC50a | IC50b | TIc | IC50 | TI | IC50 | TI | IC50 | TI | |
Methanol | 155.8 | 7.2 ± 0.2 | 21.7 | 8.39 ± 0.89 | 18.5 | 6.39 ± 0.89 | 24.3 | 9.29 ± 0.89 | 16.8 |
Ethyl Acetate | 558.2 | 10.31 ± 0.3 | 54.4 | 8.86 ± 0.35 | 62.9 | 2.87 ± 0.35 | 194.5 | 4.52 ± 0.35 | 123.5 |
Butanol | 62.1 | 14.3 ± 1.1 | 4.2 | 15.97 ± 0.15 | 3.9 | 5.97 ± 0.15 | 10.4 | 6.81 ± 0.15 | 9.1 |
Water | 917.6 | 40.8 ± 4.9 | 22.5 | 58.87 ± 0.02 | 15.6 | 8.87 ± 0.02 | 103.4 | 21.7 ± 3.1 | 42.3 |
Oseltamivir | 569.1 | 60.3 ± 5.6 | 9.5 | 37.2 ± 3.5 | 15.3 | 103.7 ± 8.75 | 5.5 | 71.6 ± 5.1 | 8.0 |
Each value was obtained from an average of three independent experiments’ standard deviation.
Concentration required to reduce MDCK cell growth by 50% (μg/mL).
Concentration required to inhibit virus infectivity by 50% (μg/mL).
Therapeutic index = CC50/IC50.