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. 2018 Jul 23;7(10):e1484981. doi: 10.1080/2162402X.2018.1484981

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© 2018 Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 3. — Maturation markers are upregulated on dendritic cells upon co-culture with EMA treated 5T33vt cells.

Murine 5T33vt myeloma cells were treated with indicated doses for 7 days with EMAs and 2 days with chemotherapy (Supplementary Figure S1I, K). Next, treated 5T33vt cells from 1 well or supernatant of treated cells was used for co-culture with primary murine DCs. One day later, DCs were analyzed for the presence of maturation markers within CD11c (+), F/40 (-), CD19 (-), CD3 (-) 7AAD (-) events. LPS was used a positive control for DC maturation.Left: Double positive for CD80/MHC-I. Middle: Double positive for CD40/MHC-I.Right: Double positive for CD86/MHC-II. Bars and error bars represent mean and standard deviation. Statistics were done using One-Way-Anova. *, **, *** indicates p < 0.05, p < 0.001, p < 0.0001, respectively. (DC = dendritic cell, cnt = control, DAC = decitabine, Quis = Quisinostat, Bz = Bortezomib, Mel = Melphalan, Mtx = Mitoxanthrone, LPS = lipopolysaccharide).