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. 2018 Aug 6;7(10):e1488565. doi: 10.1080/2162402X.2018.1488565

Table 1.

Characteristics of Akt-inhibitors.

Name Abbreviation CAS Target (IC50) Molecular weight Chemical formula Structural formula** Mechanism of inhibition
Akt inhibitor VIII Akti VIII 612847–09-3 Akt 1 (58nM)
Akt 2 (210nM)		 551.6 C34H29N7O graphic file with name koni-07-10-1488565-i001.gif Allosteric
MK-2206 MK 1032350–13-2 Akt 1 (8nM)
Akt 2 (12nM)
Akt 3 (65nM)		 480.39 C25H23Cl2N5O graphic file with name koni-07-10-1488565-i002.gif Allosteric
Triciribine TCN 35943–35-2 130nM* 320.30 C13H16N6O4 graphic file with name koni-07-10-1488565-i003.gif Allosteric
AZD5363 AZD 1143532–39-1 Akt 1 (3nM)
Akt 2 (7nM)
Akt 3 (7nM)		 428.92 C21H25ClN6O2 graphic file with name koni-07-10-1488565-i004.gif ATP-competitive
GDC-0068 GDC 1001264–89-6 Akt 1 (5nM)
Akt 2 (18nM)
Akt 3 (8nM)		 458.00 C24H32ClN5O2 graphic file with name koni-07-10-1488565-i005.gif ATP-competitive
GSK2141795 GSK1 1047634–65-0 Akt 1 (180nM)
Akt 2 (328nM)
Akt 3 (38nM)		 429.25 C18H16Cl2F2N4O2 graphic file with name koni-07-10-1488565-i006.gif ATP-competitive
GSK2110183 hydrochloride GSK2 1047645–82-8 Akt 1 (0.08nM)
Akt 2 (2nM)
Akt 3 (2.6nM)		 472.79 C18H17Cl2FN4OS.
HCl.½H2O		 graphic file with name koni-07-10-1488565-i007.gif ATP-competitive

*Not specified per isoform

**Structural formula obtained from www.chemspider.com