Figure 4.

Correlation between TIBs and CD8⁺ tumor infiltrating lymphocytes (TILs). (A) Changing of CD8 and CD8⁺ TILs-associated cytotoxic effectors expression levels as CD19 expression elevating in the KIRC cohort (TCGA). (B) Heatmap shows Spearman’s correlation coefficients of CD19 with CD8 and CD8⁺ TILs-associated cytotoxic effectors in the KIRC cohort (TCGA) and the Sato cohort. All p ≤ 0.001. (C) Representative images of co-rich infiltration of CD19⁺ TIBs and CD8⁺ TILs in one sample (up) and co-rare infiltration in another (down). Scale bar is 150 μm. (D) Comparison of CD8⁺ TILs density between CD19⁺ TIBs positive and negative groups. (E) Spearman’s correlation between CD19⁺ TIBs and CD8⁺ TILs density in mRCC patients.