Table 1.
The ten patient cases where panel-predicted visual field were consistent with SVOP results
| Patient demographics | Ophthalmology assessment outcomes | Neuroimaging outcomes | SVOP outcomes | |||||
|---|---|---|---|---|---|---|---|---|
| Case | Diagnosis and procedures prior to SVOP test | Age at SVOP test (years) | VA Right | VA Left | Confrontation and/or Goldmann visual field | Imaging description | Panel-predicted visual field on binocular testing | SVOP description |
| 1 | 1. Left optic nerve/hypothalamic pilocytic astrocytoma | 5.5 | 6/9 | NPL | Confrontation (April 2008) Complete temporal hemianopia of right eye | (July 2008) | Right hemianopia, may have some residual right-sided function |
Binocular (May 2008) Right superior quadrantanopia |
| 2. Biopsy at diagnosis | T1 post gadolinium axial image showed suprasellar hypothalamic enhancing lesion adjacent to left chiasm | |||||||
| 3. Chemotherapy completed October 2006 | ||||||||
| 2 | 1. Right optic nerve/hypothalamic pilocytic astrocytoma | 2.9 | PL | 6/9 | Confrontation Left eye complete temporal defect. Right eye “impossible” to test (October 2008) | (August 2008) | Left hemianopia, could have subtle right visual field loss in addition |
Binocular (October 2008) Left temporal hemianopia with missed points right inferior quadrant |
| 2. Right frontal craniotomy with subtotal removal January 2008 | T1 post gadolinium axial image showed residual postoperative suprasellar cystic lesion with enhancing soft tissue abutting right chiasm and right internal carotid artery | |||||||
| 4 | 1. NF1 | 3.8 | 6/9 | 6/9 | No information available | (July 2012) | Normal field, could have patchy loss |
Binocular (August 2012) Inferior scattered loss |
| 2. Spectacles for accommodative esotropia | Coronal FLAIR image showed asymmetric thickening of optic nerves and chiasm with extension into left thalamus | |||||||
| 3. Optic chiasm glioma | ||||||||
| 5 | 1. Right parieto-occipital high grade glioma | 5.1 | 6/6 | 6/6 | Confrontation fields full. (October 2011) | (January 2012) | Left hemianopia, could have superior sparing |
Binocular (December 2011) Left inferior quadrantanopia |
| 2. Surgical resection September 2011 | Goldmann unable to perform (January 2012) | T2 axial image showed Surgical resection cavity in right parieto-occipital lobe | ||||||
| 3. Focal cranial radiotherapy completed November 2011 | ||||||||
| 7 | 1. Hypothalamic ependymoma | 3.2 | 6/6 | NPL | Confrontation Difficult to test visual function (February 2010) | (September 2009) | Right hemianopia, could have some left sided loss | Binocular (November 2009) |
| 2. Fronto-temporal craniotomy and debulking of left suprasellar mass July 2009 | T1 post gadolinium axial image showed prominent right optic nerve with residual tumour in suprasellar cistern | Right hemianopia and random scattered left hemifield missed points | ||||||
| 14 | 1. Left fronto-temporal anaplastic ependymoma | 6.3 | 6/5 | 6/9 | Confrontation Examination normal (May 2011) | (April 2011) | Right hemianopia, may have inferior sparing |
Left eye (March 2011) Scattered superior and nasal loss on left monocular visual field test. Right monocular and binocular visual field both normal |
| 2. Craniotomy and excision of tumour December 2009; subsequent repeat craniotomy and excision of recurrence March 2010 | T1 post gadolinium axial image showed evidence of previous surgery and radiotherapy in left temporal lobe | |||||||
| 3. Cranial radiotherapy | ||||||||
| 15 | 1. Hypothalamic pilocytic astrocytoma | 15 | 6/36 | 6/5 | Goldmann showed incomplete left homonymous hemianopia. Some residual vision to left of vertical midline (June 2011) | (January 2011) | Left hemianopia |
Left eye (February 2011) Left hemianopia |
| 2. Biopsy and right ventriculoperitoneal (VP) shunt April 2010; Left VP shunt August 2010 | T1 post gadolinium axial image showed hypothalamic tumour with central necrosis and peripheral enhancement post-radiotherapy | |||||||
| 3. Focal radiotherapy November 2010 | ||||||||
| 16 | 1. Left temporal pilocytic astrocytoma | 4.4 | 6/5 | 6/6 | Confrontation showed signs of right homonymous hemianopia | (September 2009) | Right hemianopia |
Binocular (October 2009) Right hemianopia with missed points on left side |
| 2. Left fronto-temporal craniotomy and debulking September 2009 | (October 2009) | T2 axial image showed left temporal resection cavity with medial extension of residual tumour in left thalamus and compression of chiasm | ||||||
| 3 | 1. NF1 | 10.7 | 6/6 | 6/6 | Goldmann Within normal limits (April 2012) | (September 2011) | Normal field |
Binocular (February 2012) Normal field |
| 2. Right optic tract thickening—possibly small glioma, T2 hyperintensity Left internal capsule | Coronal FLAIR image showed T2 hyperintensities in the globus pallidus bilaterally, in keeping with NF1 | |||||||
| 3. Poor motor co-ordination and dyspraxia | ||||||||
| 6 | 1. Posterior fossa ependymoma - mainly L cerebellar pontine angle | 5.2 | 6/6 | 6/6 | Confrontation fields full (June 2010) | (January 2011) | Normal field |
Binocular (January 2011) Normal field |
| 2. Posterior fossa craniotomy and complete excision November 2009 | T1 post gadolinium axial image showed left posterior fossa surgical resection cavity | |||||||
| 3. Proton beam radiotherapy completed March 2010 | ||||||||
Patients with abnormal visual fields are listed before those with normal fields
Details included are (1) Patient demographics (diagnosis and procedures prior to SVOP test and age at SVOP test), (2) Ophthalmology assessment outcomes (VA and confrontation and Goldmann perimetry if attempted), (3) Neuroimaging outcomes (a scan image and subsequent panel-predicted visual field), and (4) The SVOP test outcomes (SVOP plot and visual field description).
VA visual acuity, NPL no perception of light, PL perception of light, NF1 Neurofibromatosis type 1, SVOP Saccadic Vector Optokinetic Perimetry