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. Author manuscript; available in PMC: 2018 Oct 3.
Published in final edited form as: Nature. 2017 Mar 22;543(7647):714–718. doi: 10.1038/nature21703

Extended Data Figure 6.

Extended Data Figure 6

Expected proportion of early embryonic mutations shared by cancer according to the cell generation gap between the MRCA cell of adult blood cells and the MRCA cell of all somatic cells.

a, (see Supplementary Discussion 4) A scenario when there is no cell generation gap. Early mutations are represented by asterisks in colors. A summary of the expected proportion of mutations shared with cancer cells is shown in the table: the chance is twice the VAF of each early embryonic mutation.

b, A scenario when the MRCA cell of adult blood cells is formed one cell generation later than the MRCA cell of all somatic cells. The chance is identical to the VAF of each early embryonic mutation.

c, A scenario when the MRCA cell of adult blood cells is formed two cell generations later than the MRCA cell of all somatic cells. The chance is half the VAF of each early embryonic mutation.