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. Author manuscript; available in PMC: 2018 Oct 3.
Published in final edited form as: Nature. 2017 Mar 22;543(7647):714–718. doi: 10.1038/nature21703

Figure 2. Features of early embryonic mutations.

Figure 2

(a) An example of an embryonic mutation non-shared with cancer. The minimal low VAF (2.6%) observed in the tumor ultrahigh-depth amplicon sequencing is consistent with a contaminating population of mutant non-neoplastic cells.

(b) An example of an embryonic mutation shared with cancer. The high VAF (42.1%) in the tumour ultrahigh-depth amplicon sequencing is consistent with a clonal mutation in cancer cells and a contaminating population of wild-type non-neoplastic cells.

(c) The proportion of shared mutations correlates with the VAF of mutations in blood.