Table 1.
Baseline characteristics of patients using study medications
| Cefixime | Ciprofloxacin | Levofloxacin | Ofloxacin | Moxifloxacin | |
| No of subjects | 402 930 | 1 466 133 | 1 141 961 | 1 830 786 | 47 080 |
| Age, mean±SD | 49.3±17.7 | 48.5±17.3 | 50.4±16.7 | 50.3±16.9 | 58.4±17.4 |
| No of females (%) | 238 329 (59.1) | 951 813 (64.9) | 643 076 (56.3) | 1 120 119 (61.2) | 23 586 (50.1) |
| No of comorbidities (%) | |||||
| Hypertension | 121 529 (30.2) | 410 360 (28.0) | 346 918 (30.4) | 540 934 (29.5) | 21 690 (46.1) |
| Diabetes mellitus | 97 779 (24.3) | 321 483 (21.9) | 268 447 (23.5) | 382 877 (20.9) | 17 977 (38.2) |
| Acute myocardial infarction | 6536 (1.6) | 17 451 (1.2) | 15 209 (1.3) | 11 731 (1.0) | 1292 (2.7) |
| Ischaemic heart disease | 45 810 (11.4) | 137 303 (9.4) | 122 740 (10.7) | 161 602 (8.8) | 9408 (20) |
| Cardiomyopathy | 1450 (0.4) | 3668 (0.3) | 3443 (0.3) | 3924 (0.2) | 438 (0.9) |
| Valve disorder | 1826 (0.5) | 4971 (0.3) | 4643 (0.4) | 6219 (0.3) | 513 (1.1) |
| Arrhythmia | 14 387 (3.6) | 45 727 (3.1) | 38 751 (3.4) | 53 536 (2.9) | 2761 (5.9) |
| Congestive heart failure | 21 753 (5.4) | 59 507 (4.1) | 55 276 (4.8) | 68 471 (3.7) | 5724 (12.2) |
| Congenital heart disease | 550 (0.1) | 1599 (0.1) | 1430 (0.1) | 1894 (0.1) | 110 (0.2) |
| Cancer | 43 336 (10.8) | 128 612 (8.8) | 118 618 (10.4) | 122 116 (6.7) | 10 285 (21.8) |
| Cerebrovascular disease | 42 741 (10.6) | 127 394 (8.7) | 113 241 (9.9) | 155 453 (8.5) | 8389 (17.8) |
| Renal disease | 27 440 (6.8) | 93 946 (6.4) | 73 935 (6.5) | 83 202 (4.5) | 5657 (12) |
| Arterial disease | 58 202 (14.4) | 201 275 (13.7) | 173 004 (15.1) | 268 362 (14.7) | 9298 (19.7) |
| Venous thromboembolism | 5613 (1.4) | 15 375 (1.0) | 14 016 (1.2) | 16 571 (0.9) | 1704 (3.6) |
| Dementia | 17 245 (4.3) | 48 445 (3.3) | 41 097 (3.6) | 46 626 (2.5) | 4046 (8.6) |
| Rheumatic disease | 29 610 (7.3) | 97 980 (6.7) | 77 971 (6.8) | 112 629 (6.2) | 4453 (9.5) |
| Peptic ulcer disease | 148 247 (36.8) | 527 527 (36.0) | 418 871 (36.7) | 636 452 (34.8) | 21 304 (45.3) |
| Chronic lung disease | 215 194 (53.4) | 633 215 (43.2) | 586 894 (51.4) | 810 357 (44.3) | 36 096 (76.7) |
| No of antibiotic indications (%) | |||||
| Upper respiration infection | 41 000 (10.2) | 34 919 (2.4) | 71 542 (6.3) | 200 376 (10.9) | 2024 (4.3) |
| Pneumonia | 17 362 (4.3) | 13 792 (0.9) | 54 016 (4.7) | 10 048 (0.5) | 10 567 (22.4) |
| Other respiratory infection | 31 943 (7.9) | 49 097 (3.3) | 118 629 (10.4) | 266 793 (14.6) | 2898 (6.2) |
| Gastrointestinal infection | 10 997 (2.7) | 258 359 (17.6) | 26 806 (2.3) | 116 001 (6.3) | 142 (0.3) |
| Urinary tract infection | 24 497 (6.1) | 477 439 (32.6) | 255 878 (22.4) | 204 458 (11.2) | 396 (0.8) |
| Genitourinary infection | 10 357 (2.6) | 103 874 (7.1) | 104 759 (9.2) | 75 822 (4.1) | 806 (1.7) |
| Skin/wound infection | 15 212 (3.8) | 13 240 (0.9) | 20 509 (1.8) | 47 573 (2.6) | 589 (1.3) |