Figure 3.

“Re-anchoring” of soluble forms of ligands and receptors by their binding to extracellular matrix components. Various reported effects of extracellular matrix components on the functions of soluble ligands and receptors, shown in the lower part of the figure, are compared with the functions of soluble ligands and receptors in the absence of such components, as shown in the upper part. See text for details and for numbering of the illustrated effects. Undulating lines correspond to extracellular matrix components. Orange forms correspond to structural motifs that dictate binding to such components.