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. 2018 Oct 1;32(19-20):1285–1296. doi: 10.1101/gad.316547.118

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© 2018 Priesnitz and Becker; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — Feedback loop regulation of cytochrome b synthesis. The translational activators Cbp1, Cbs1, Cbs2, and Cbp3/Cbp6 promote the translation of COB mRNA to produce cytochrome b (Cyt b) in yeast mitochondria. The Cbp3/Cbp6 complex remains bound to membrane-inserted cytochrome b and facilitates insertion of heme b and association of the assembly factor Cbp4. Binding of the nuclear-encoded subunits Qcr8 and Qcr7 as well as the insertion of the second heme b molecule into cytochrome b promote dissociation of the Cbp3/Cbp6 complex. The released Cbp3/Cbp6 complex can stimulate further rounds of translation of COB mRNA. (b) Heme b.