Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct;28(10):1427–1441. doi: 10.1101/gr.237826.118

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Wang et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Figure 1. — Mapping and statistics of conserved PASs in mammals. (A) Mapping PASs in human, mouse, and rat genomes using 3′READS or 3′READS+ data, and identification of conserved PASs using the reciprocal best-match method. (B) Percentage of PASs conserved in human, mouse, and rat genomes. Two types of conservation are shown, i.e., conserved in mammals (human versus mouse or rat) and conserved in rodents only. Total number of PASs mapped for each species is shown. (C) Percentage of conserved PASs of different gene groups. The number of PASs in each group is indicated. The “other” group contains PASs from overlapping genes (on the same strand) and pseudogenes. (D) Percentage of mRNA or lncRNA genes with conserved PASs. The average number of PASs per gene (with or without conservation in mammals) is indicated. (E) APA sites in different loci of an mRNA gene. The sites are grouped into last exon (LE) or upstream region (UR). (F) Percentage of conserved UR and LE PASs of mRNA genes. (G) Percentage of genes with conserved APA sites in UR, LE, or both; UR APA conservation requires a gene to contain at least one conserved UR PAS, and LE APA conservation requires a gene to contain at least two conserved LE PASs.