Table 3. Probabilistic costs, health outcomes, and cost per UTI resolved per treatment regimen modelled.

	Total cost, £	UTIs resolved, n	Cost per UTI resolved, £
			Baseline sensitivity analyses		Scenarios
			Probabilistic	Deterministic	A	B	C
Trimethoprim 200 mg twice daily for 7 days	60	857	70	69	69	91	73
Fosfomycin 3 g once	65	842	78	77	80	77
Nitrofurantoin (MR) 100 mg twice daily for 7 days	69	849	82	81	87	84	100
Pivmecillinam 200 mg twice daily for 7 days	67	766	88	96	98	99
Nitrofurantoin 50 mg four times a day for 7 days	78	799	98	97	104	101
Pivmecillinam 200 mg three times a day for 7 days	78	753	103	103	106	106
Pivmecillinam 400 mg twice daily for 3 days	78	704	111	111	114	114
Trimethoprim 200 mg once	81	609	133	131	130	161
Nitrofurantoin 100 mg four times a day for 3 days	87	631	138	139	147	144

Note: treatments ordered by lowest cost per UTI resolved.

Baseline analysis compared with the two deterministic scenarios tested: A = resistance rates from pathogens other than E. coli; B = updated resistance measures for trimethoprim, nitrofurantoin, and pivmecillinam; and C = estimated effectiveness for 3-day dosing, which is in line with the current guidance from Public Health England for use of these treatments. MR = modified release. UTI = urinary tract infection.