Figure 3.

The K-Ras membrane anchor encodes a highly specific capacity for lipid binding. The precise amino acid sequence of the polybasic domain (PBD) and prenyl group encodes lipid-binding specificity that is realized as a defined anchor structure. Aggregation of a set of like anchors leads to assembly of nanoclusters with defined lipid compositions (shown as a heat map). The lipid composition of the resulting nanocluster shapes signal output (shown as a heat map of signaling pathway activity) (Zhou et al. 2017). LBI, Lipopolysaccharide-binding index.