Table 3.
Diagnostic performance of multimodality imaging in breast cancer (Sensitivity and Specificity)
| Author Year | Accrual period | Subject number of research | Mammography | US | MRI | PET |
|---|---|---|---|---|---|---|
| BCSC data through 2009 (Consortium) | 2004–2008 | 363,048 Diagnostic Mammography Examinations | SE =84.4% SP=91.3% |
- | - | - |
| (Kolb, et al. 2002) | 1995–2000 | 11,130 asymptomatic mean age,63.7 years |
total SE=77.6% ≤49y SE=58% >50y SE=82.7% total SP=98.8% |
total SE=75 3%
≥49ySE=78.6% ≥50y SE=74% total SP=96 8% |
||
| (Saarenmaa, et al. 2001) | 1996–1997 | 572 breast cancer cases age groups 26–49. 50–59 and 60–92 |
SE=0.93% Increased by age, fattiness of breast OR=0.2,0.4 |
SE=0.86% Decreased by age OR=2.3 Increased by fattmess of the breast OR=O.S |
||
| (Houssami, et al. 2003) | 1994– 1996 | 480 25–55 years 240 with breast cancer 240 age-matched women not having cancer |
total SE=75.8%
≤45ySE=71.7% 46–55 fr- SE=79.1% total SP =87.6% |
total SE=81.7% ≤45 v SE=84.9% 46–55y SE=79.1% total SP =88.0% |
||
| (Shen, et al. 2015) | 2008–2010 | 13 339 high-nsk women 30–65 years |
SE=57.1% SP =100% diagnostic accuracy =76.6% PPY=72.7% |
SE=100% SP =99.9% diagnostic accuracy =99 9% PPV=70.0% |
||
| (Berg, et al. 2004) | 1999–2002 | 177 malignant foci in 121 cancerous
breasts |
SE=67.8% %SP =75% |
SE=83.0% SP =34% |
SE=94.4% SP =26% |
- |
| (Kuhl, et al. 2005) | 1996–2002 mean follow- up of 5.3 |
529 asymptomatic women who were
suspected or proven to have a breast cancer susceptibility gene (3RCA) |
SE=32.6% SP =96.8% |
SE=39.5% SP =90.5% |
SE=90.7% SP=97.2% |
- |
| (Kuhl, et al. 2000) | 1996–1998 | 192 asymptomatic women proven or
suspected to be earners of a breast cancer susceptibility gene. |
SE=33% PPV=30% |
SE=33% PPV=12% |
SE=100% PPY=64% |
|
| (Leach, et al. 2005) | 1997– 2004 | 649 patients with a strong family history
of breast cancer or a high probability of a BRCA1. BRCA2. or TP53 mutation |
SE=40% SP =93% |
SE=77% SP =81% |
||
| (Sardanelli. et al. 2011) | 2000–2007 | 501 women with a high genetic nsk | SE=50% SP =99®. |
SE=52% SP =98.4% | SE=91% SP=96.7% |
|
| (Warner, et al. 2008) | Data bases 1995–2007 | Summarized 11 studies that screened
women at very high risk for breast cancer |
SE=32% SP =94.7% |
SE=75% SP=96.1% |
||
| (Zhang, et aL 2014) | 2006–2012 | 164 patients with invasive breast cancer | - | - | - | SE=86% |
| (Song, et al 2015) | 2008–2012 | 86 patients with invasive breast cancer
Detecting multifocality in breast cancer patients |
SE=66.7% SP=89.5% |
SE=83.3% SP=711% |
SE=100% SP=61.8% |
SE=33.3% SP=93.4 % |
| (Berg, et al 2011) | 2006–2008 | 388 women with invasive and. or
intraductal breast cancer |
SE=80.7% SP=86 3% P PV=53% |
For
PEM SE=80.5% SP=91.2% PPY=66% |
||
| (Berg, et al. 2006) | 94 consecutive women with known breast cancer |
For
PEM SE=90 SP=86 PPV=88 NPV=88 Accuracy=88 |
||||