Figure 2.
Filament structure of proto-PrPSc and its stabilizing network of hydrogen bonds. a, Structure of proto-PrPSc determined by MicroED shown as an assembly of ten chains. Distances between strands and sheets, and the fibril growth axis are labeled. b, A view down the fibril axis highlighting the interface between adjacent sheets. An orange circle denotes the direction of the fibril axis. c, Front and d, back views of the fibril with two strands representing a sheet. Polar contacts are labeled as orange arrows for intra-chain and blue arrows inter-chain.