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The effects of withdrawal from intermittent and continuous nicotine exposure on brain reward thresholds (A and C, respectively) and response latencies (B and D, respectively). Data are presented as a percentage of baseline thresholds/latencies (mean ± SEM) before nicotine/saline exposure. Asterisks denote statistically significant differences between corresponding groups of nicotine- and saline-exposed rats (**p < 0.01, *p < 0.05, LSD post hoc test).
