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. 2018 Oct 1;138(14):1387–1398. doi: 10.1161/CIRCULATIONAHA.117.033200

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© 2018 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 4. — Forest plots showing hazard ratios (HRs) for the composite end points and their individual components, comparing sarcomere mutation carriers (SARC+), patients with hypertrophic cardiomyopathy (HCM) without sarcomere mutations (SARC−), and carriers of a variant of unknown significance (SARC VUS) cohorts. A, SARC+ vs SARC−: Sarcomere mutation carriers have a higher risk of all individual components of the composite end points compared with patients with HCM without sarcomere mutations. B, SARC VUS vs SARC−: SARC VUS patients have a higher risk of the overall composite end point, death, appropriate implantable cardioverter-defibrillator (ICD) firing, atrial fibrillation, and heart failure (HF) with ejection fraction (EF) >55%. C, SARC+ vs SARC VUS: SARC+ and SARC VUS patients have similar risks except for a markedly higher hazard for left ventricular (LV) EF <35% and need for cardiac transplantation or ventricular assist device (VAD) in SARC+ patients. NYHA indicates New York Heart Association.