(A) Schematic of the bone marrow (BM) chimera experiment.
(B and C) Bacterial burdens per liver (B) and serum IL-18 (C) in lethally irradiated B6 versus B6.Il18−/− recipients of B6.Il18−/− or B6 BM, respectively, harvested at 72 hpi with 104 Lm i.v. (n = 2 independent experiments with 3–5 mice per group).
(D and E) Serum IL-18 (D) and IL-10 (E) detected in lethally irradiated BM recipients at 72 hpi.
(F) Lm burdens per the livers of BM recipients at 72 hpi (data pooled from n = 2 independent experiments with 3–5 mice per group, repeated a third time with similar results).
Data are displayed as mean ± SEM; *p < 0.05 and **p < 0.01 as measured by t test (B and C) or ANOVA (D–F).