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. Author manuscript; available in PMC: 2018 Oct 3.
Published in final edited form as: Cell Rep. 2018 May 29;23(9):2582–2594. doi: 10.1016/j.celrep.2018.04.106

Figure 7. Batf3-Dependent Cells Are a Vital Source of IL-18 that Regulates NK Cell IL-10 Responses during Lm Infection.

Figure 7

(A) Schematic of the bone marrow (BM) chimera experiment.

(B and C) Bacterial burdens per liver (B) and serum IL-18 (C) in lethally irradiated B6 versus B6.Il18−/− recipients of B6.Il18−/− or B6 BM, respectively, harvested at 72 hpi with 104 Lm i.v. (n = 2 independent experiments with 3–5 mice per group).

(D and E) Serum IL-18 (D) and IL-10 (E) detected in lethally irradiated BM recipients at 72 hpi.

(F) Lm burdens per the livers of BM recipients at 72 hpi (data pooled from n = 2 independent experiments with 3–5 mice per group, repeated a third time with similar results).

Data are displayed as mean ± SEM; *p < 0.05 and **p < 0.01 as measured by t test (B and C) or ANOVA (D–F).