Table 4. Intraclass correlation coefficients for repeat urinary concentrations of phenols and phthalate metabolites (SG adjusted) before and after adjustment for potential sources of variability unrelated to exposure pathways.
Biomarker | Unadjusted ICC (95% CI) | Adjusted1 ICC (95% CI) | Previous literature in pregnant women |
---|---|---|---|
ICCs adjusted for urinary concentration2 | |||
Bisphenol A | 0.24 (0.10, 0.49) | 0.20 (0.06, 0.47) | 0.04 – 0.31 4, 10-13, 26, 47, 48 |
2,4-dichlorophenol | 0.43 (0.24, 0.64) | 0.46 (0.25, 0.68) | 0.38 – 0.60 10, 11 |
2,5-dichlorophenol | 0.34 (0.16, 0.57) | 0.39 (0.20, 0.62) | 0.49 – 0.61 10, 11 |
Butyl Paraben | 0.56 (0.36, 0.74) | 0.59 (0.38, 0.76) | 0.38 – 0.56 10, 11, 13, 49 |
Methyl Paraben | 0.44 (0.25, 0.65) | 0.42 (0.22, 0.64) | 0.24 – 0.61 10, 11, 13, 49 |
Propyl Paraben | 0.56 (0.36, 0.74) | 0.54 (0.34, 0.73) | 0.32 – 0.62 10, 11, 13, 49 |
Monoethyl phthalate | 0.68 (0.50, 0.82) | 0.66 (0.46, 0.81) | 0.21 – 0.50 12, 24-27 |
ΣDEHP metabolites | 0.32 (0.15, 0.55) | 0.27 (0.10, 0.57) | 0.08 – 0.31 12, 24-27 |
Abbreviations: ΣDEHP metabolites, sum of metabolites of di(2-ethylhexyl) phthalate; ICC, intraclass correlation coefficient
Adjusted for gestational age, weight gain, time since awoke, time slept, time since last food/drink, and time since last void.
When ICCs for ΣDEHP metabolites were not available, the mean ICC for the four individual metabolites was reported