Table 5. Sensitivity, specificity, and percent correct classified (as high vs. low average exposure across pregnancy1) using biomarker concentrations in a single pregnancy urine.
| 16-18 wks | 20-22 wks | 23-26 wks | 27-30 wks | 32-33 wks | 35-36 wks | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| Unadjusted | Adjusted2 | Unadjusted | Adjusted2 | Unadjusted | Adjusted2 | Unadjusted | Adjusted2 | Unadjusted | Adjusted2 | Unadjusted | Adjusted2 | ||
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| Bisphenol A (μg/L) | % Crct | 74% | 58%-74% | 74% | 63%-74% | 74% | 58%-79% | 74% | 79%-89% | 84% | 89%-100% | 74% | 58%-74% |
| Sens/Spec | 0.57/0.83 | 0.33-0.57/0.69-0.83 | 0.57/0.83 | 0.43-0.57/0.75-0.83 | 0.57/0.83 | 0.33-0.67/0.69-0.85 | 0.57/0.83 | 0.67-0.83/0.85-0.92 | 0.71/0.92 | 0.83-1.0/0.92-1.0 | 0.57/0.83 | 0.33-0.57/0.69-0.83 | |
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| 2 4-Dichlorophenol (μg/L) | % Crct | 84% | 84%-89% | 84% | 63%-79% | 84% | 79%-100% | 84% | 89%-95% | 63% | 68%-84% | 74% | 63%-84% |
| Sens/Spec | 0.71/0.92 | 0.71-0.83/0.92-0.92 | 0.71/0.92 | 0.43-0.67/0.75-0.85 | 0.71/0.92 | 0.67-1.0/0.85-1.0 | 0.71/0.92 | 0.83-0.86/0.92-1.0 | 0.43/0.75 | 0.50-0.71/0.77-0.92 | 0.57/0.83 | 0.43-0.71/0.75-0.92 | |
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| 2 5-Dichlorophenol (μg/L) | % Crct | 84% | 68%-89% | 84% | 89%-100% | 95% | 79%-95% | 84% | 74%-89% | 63% | 58%-79% | 74% | 68%-79% |
| Sens/Spec | 0.71/0.92 | 0.50-0.83/0.77-0.92 | 0.71/0.92 | 0.83-1.0/0.92-1.0 | 0.86/1.00 | 0.67-0.86/0.85-1.0 | 0.71/0.92 | 0.57-0.83/0.83-0.92 | 0.43/0.75 | 0.33-0.67/0.69-0.85 | 0.57/0.83 | 0.50-0.67/0.77-0.85 | |
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| Butyl Paraben (μg/L) | % Crct | 74% | 58%-74% | 84% | 63%-89% | 74% | 63%-89% | 84% | 68%-84% | 84% | 79%-100% | 84% | 79%-100% |
| Sens/Spec | 0.57/0.83 | 0.33-0.57/0.69-0.83 | 0.71/0.92 | 0.43-0.83/0.75-0.92 | 0.57/0.83 | 0.43-0.83/0.75-0.92 | 0.71/0.92 | 0.50-0.71/0.77-0.92 | 0.71/0.92 | 0.67-1.0/0.85-1.0 | 0.71/0.92 | 0.67-1.0/0.85-1.0 | |
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| Methyl Paraben (μg/L) | % Crct | 83% | 61%-83% | 79% | 74%-89% | 79% | 68%-84% | 79% | 74%-89% | 56% | 44%-56% | 89% | 68%-84% |
| Sens/Spec | 0.67/0.92 | 0.33-0.67/0.75-0.92 | 0.67/0.85 | 0.57-0.83/0.83-0.92 | 0.67/0.85 | 0.50-0.71/0.77-0.92 | 0.67/0.85 | 0.57-0.83/0.83-0.92 | 0.20/0.69 | 0.00-0.29/0.62-0.73 | 0.83/0.92 | 0.50-0.71/0.77-0.92 | |
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| Propyl Paraben (μg/L) | % Crct | 84% | 63%-79% | 84% | 79%-95% | 74% | 68%-89% | 74% | 74%-95% | 74% | 58%-79% | 74% | 68%-89% |
| Sens/Spec | 0.71/0.92 | 0.43-0.67/0.75-0.85 | 0.71/0.92 | 0.67-0.86/0.85-1.0 | 0.57/0.83 | 0.50-0.83/0.77-0.92 | 0.57/0.83 | 0.57-0.86/0.83-1.0 | 0.57/0.83 | 0.33-0.67/0.69-0.85 | 0.57/0.83 | 0.50-0.83/0.77-0.92 | |
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| Monoethyl phthalate (μg/L) | % Crct | 79% | 68%-79% | 79% | 74%-79% | 100% | 89%-100% | 89% | 84%-95% | 89% | 74%-95% | 89% | 79%-95% |
| Sens/Spec | 0.67/0.85 | 0.50-0.67/0.77-0.85 | 0.67/0.85 | 0.57-0.67/0.83-0.85 | 1.00/1.00 | 0.83-1.0/0.92-1.0 | 0.83/0.92 | 0.71-0.86/0.92-1.0 | 0.83/0.92 | 0.57-0.86/0.83-1.0 | 0.83/0.92 | 0.67-0.86/0.85-1.0 | |
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| ΣDEHP metabolites (μmol/L) | % Crct | 79% | 63%-79% | 79% | 68%-74% | 89% | 79%-89% | 79% | 58%-74% | 79% | 68%-74% | 79% | 63%-89% |
| Sens/Spec | 0.67/0.85 | 0.43-0.67/0.75-0.85 | 0.67/0.85 | 0.50-0.57/0.77-0.83 | 0.83/0.92 | 0.67-0.83/0.85-0.92 | 0.67/0.85 | 0.33-0.57/0.69-0.83 | 0.67/0.85 | 0.50-0.57/0.77-0.83 | 0.67/0.85 | 0.43-0.83/0.75-0.92 | |
Abbreviations: ΣDEHP metabolites: sum of metabolites of di(2-ethylhexyl) phthalate; % Crct: percent correctly classified; Sens: sensitivity; Spec: Specificity
1
Estimated using the mean of the residuals for the 6 urines collected across pregnancy.
2
Adjusted analyses use imputed variables and results presented are the range of values across the 10 imputed datasets. Estimates are adjusted for gestational age, weight gain, time since awoke, time slept, time since last food/drink, and time since last void.