Table 1. SUMMARY OF PHARMACOKINETICS FOR FLURBIPROFEN AND 4’-OH-FLURBIPROFEN.
| Arithmetic Mean ± SD (n=12) | |||||
|---|---|---|---|---|---|
| FLURBIPROFEN | Control | Fluconazole | Pomegranate Juice | Pomegranate Extract | F value (ANOVA) |
| AUC0−∞ (μg/mL x hr) | 59.3 ± 18.7 | 113.8 ± 22.9* | 61.6 ± 16.6 | 61.5 ± 13.9 | 72.4 (P < 0.001) |
| CL/F (mL/min) | 30.7 ± 9.7 | 15.2 ± 2.8* | 28.7 ± 6.8 | 28.5 ± 7.1 | 23.3 (P < 0.001) |
| Cmax (μg/mL) | 9.8 ± 4.3 | 13.9 ± 4.0* | 9.7 ± 2.6 | 9.6 ± 1.8 | 6.64 (P = 0.001) |
| Tmax(hr)‡ | 1.75 (1–3) | 1.5 (0.5–4) | 2 (1–4) | 1.75 (0.5–4) | 0.44 (P = N.S.) |
| T1/2 (hr) | 3.9 ± 1.1 | 6.5 ± 1.7* | 4.0 ± 0.7 | 4.2 ± 1.0 | 24.7 (P < 0.001) |
| 4’-OH-FLURBIPROFEN | Control | Fluconazole | Pomegranate Juice | Pomegranate Extract | F value (ANOVA) |
| AUC0–12 (μg/mL * hr) | 3.3 ± 1.3 | 2.3 ± 0.9* | 3.5 ± 1.0 | 3.4 ± 1.1 | 13.3 (P < 0.001) |
| Cmax (μg/mL) | 0.6 ± 0.4 | 0.3 ± 0.1* | 0.6 ± 0.2 | 0.6 ± 0.2 | 8.01 (P < 0.001) |
| Tmax (hr)‡ | 2.5 (1–6) | 2 (1.5–4) | 3 (1–4) | 3 (1–5) | 0.27 (P = N.S.) |
| FLURBIPROFEN | Geometric mean (90% confidence interval) | ||||
| AUC (μg/mL x hr) | 56.8 (48.4–66.6) | 111.8 (101.0–123.7) | 59.7 (52.3–68.2) | 60.0 (53.1–67.9) | |
| Cmax (μg/mL) | 9.1 (7.5–11.0) | 13.4 (11.5–15.5) | 9.4 (8.1–10.8) | 9.4 (8.6–10.4) | |
‡
Median and range
*
denotes significant difference (P < 0.05) versus control based on Dunnett’s test