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Schematic representation of the membrane topology of LRRC8A and interacting molecules. The 2 opposite orientations that LRRC8A potentially assumes (A and B) and their distinct roles in T-cell signaling (orientation A) and VRAC activity (orientation B) are shown. The LRRC8A region lacking in the ebo mutant is shown in light blue. GAB2, GRB2-associated-binding protein 2; GRB2, growth factor receptor-bound protein 2; PI3K, phosphoinositide 3-kinase.
