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. Author manuscript; available in PMC: 2018 Oct 3.
Published in final edited form as: Xenobiotica. 2010 May;40(5):306–318. doi: 10.3109/00498251003596817

Figure 1. PKC inhibitor screen evaluating the effect of ten different PKC isoform selective and non-selective inhibitors on acetaminophen glucuronidation in LS180 cells.

Figure 1.

Calphostin-C, curcumin, hypericin, and valproic acid are considered pan PKC inhibitors, while the other inhibitors selected have some selectivity for specific PKC isoforms. NPC-15437 at 100 μM resulted in the detachment of the LS180 cells from the culture plates after 2 hours with complete cell lysis by 26 hours (overt toxicity). Data points correspond to the mean of duplicate determinations performed on the same day.