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. 2018 Oct 3;8:14770. doi: 10.1038/s41598-018-32878-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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p53 translocates to mitochondria in poorly perfused brain sections. In well-perfused brains (upper row), p53 immunolabeling (red) exhibits a predominantly diffuse cytoplasmic staining (b) and occasional colocalization with mitochondria visualized with mitotracker-green (arrows, green, a). (c) illustrates the nuclei identified by Hoechst staining (blue) on a merged image of (a and b). In poorly perfused brain sections (lower row), p53 immunopositive granules (arrowheads, red, e) sharply colocalize with mitochondria (arrowheads, green, d). (f) Illustrates the nuclei identified by Hoechst staining (blue) on the merged image of (d and e). Triangles point at a swollen donut-like stained nucleus. Insets show magnified images. Images were taken at 0.2 µm thickness by laser scanning confocal microscope. Scale bars: 5 µm.