Table 3.
The comprehensive information list of 18 enzymes related to pAp metabolism.
| NO | Gene name |
Protein name | Catalytic activity | Gene location |
|---|---|---|---|---|
| 1 | AASD- HPPT | L-aminoadipate-semialdehyde dehydrogenase-phosphopante- theinyl transferase |
CoA-[4′-phosphopantetheine] + apo-ACP = pAp + holo-ACP | 11q22.3 |
| 2 | NDST2 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 | PAPS + [heparan sulfate]-glucosamine = pAp + [heparan sulfate]-N-sulfoglucosamine (glucosamine 3-sulfate) catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) |
10q22.2 |
| 3 | NDST4 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 | same as above | 4q26 |
| 4 | HS3ST2 | Heparan sulfate glucosamine 3-O-sulfotransferase 2 | PAPS + [heparan sulfate]-glucosamine = pAp + [heparan sulfate]-glucosamine 3-sulfate | 16p12.2 |
| 5 | HS3ST4 | Heparan sulfate glucosamine 3-O-sulfotransferase 4 | Same as above | 16p12.1 |
| 6 | HS3ST5 | Heparan sulfate glucosamine 3-O-sulfotransferase 5 | Same as above | 6q21- q22.1 |
| 7 | HS6ST3 | Heparansulfate glucosamine 6-O-sulfotransferase 3 | PAPS + [heparan sulfate]-glucosamine = pAp + [heparan sulfate]-glucosamine 6-sulfate | 13q32.1 |
| 8 | CHST3 | Carbohydrate sulfotransferase 3 |
PAPS + chondroitin = pAp + chondroitin 6′-sulfate | 10q22.1 |
| 9 | CHST7 | Carbohydrate sulfotransferase 7 |
Same as above | Xp11.3 |
| 10 | CHST12 | Carbohydrate sulfotransferase 12 |
PAPS + chondroitin = pAp + chondroitin 4′-sulfate | 7p22.3 |
| 11 | CHST15 | Carbohydrate sulfotransferase 15 |
PAPS + [dermatan/chondroitin]-4-O-sulfo-N-acetylgalactosamine = pAp + [dermatan/chondroitin]-4,6-di-O-sulfo-N- acetyl-D-galactosamine |
10q26.13 |
| 12 | TPST1 | Protein-tyrosine sulfotransferase 1 | PAPS + protein tyrosine = pAp + protein tyrosine- O-sulfate | 7q11.21 |
| 13 | TPST2 | Protein-tyrosine sulfotransferase 2 | Same as above | 22q12.1 |
| 14 |
GAL3-
ST1 |
Galactosylceramide sulfotransferase | PAPS + a galactosylceramide = pAp + a galactosyl ceramidesulfate PAPS + monogalactosylalkylacylglycerol = pAp + monogalactosylalkylacylglycerol sulfate | 22q12.2 |
| 15 | PAPSS1 | Bifunctional PAPS synthase 1 | ATP + sulfate = diphosphate + AMP-SO3− (APS) ATP + AMP-SO3− (APS) = ADP + PAPS |
4q25 |
| 16 | PAPSS2 | Bifunctional PAPS synthase 2 | Same as above | 10q23.2- q23.31 |
| 17 | IMPAD1 | Inositol monophosphatase 3 | Myo-inositol phosphate + H2O = myo-inositol + phosphate pAp + H2O = 5′-AMP + phosphate | 8q12.1 |
| 18 | BPNT1 | 3′(2′),5′-bisphosphate nucleotidase 1 | pAp + H2O = 5′-AMP + phosphate | 1q41 |
Foot notation: CoA: Coenzyme A; ACP: acylcarrier protein; PAPS: Phosphoadenosine phosphosulfate; pAp: 3′-Phosphoadenylate; APS: Adenosine-5′-phosphosulfate. Data was compiled according to HMDB 2018.