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. 2018 Oct 3;8:14741. doi: 10.1038/s41598-018-33072-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Phenotypic and genetic analysis of ß-lactam genes. (A) A heatmap of three ß-lactam associated genes shows the down regulation (red) of carO and the up regulation (green) of ampC and bla_OXA51-like. (B) Disk-diffusion assays were performed and changes in the halo of inhibition were recorded for cefazolin (CZ), ampicillin (AMP), ceftazidime (CAZ), cefepime (FEP), imipenem (IMP) and meropenem (MEM). The photographs depict the results of (C) an imipenem (IPM) disk diffusion assay and (D) a meropenem (MP) E-test assay for A118 cells cultured with and without HSA.