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. 2018 Feb 22;32(10):2152–2166. doi: 10.1038/s41375-018-0033-0

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© The Author(s) 2018

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Fig. 3 — Neocentromere at ring chromosomes harboring 8q24 amplicons. Immuno-FISH co-hybridization results in cases MLL_11929 (a), MLL_11933 (b), #18 (c), and #30 (d) display ring chromosomes with MYC amplifications (green) positive for CENP-A (red) but negative for alpha-satellite DNA (blue). Square boxes at the bottom left of each panel show the DAPI image of the rings