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. 2018 Feb 22;32(10):2152–2166. doi: 10.1038/s41375-018-0033-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, and provide a link to the Creative Commons license. You do not have permission under this license to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — Chimeric transcripts significantly associated with a peculiar gene expression profile at amplified regions and breakpoints. a Heatmap of 8q24 gene expression levels in our AML-amp cohort. b Box and Whisker plots illustrating differences in the number of breakpoints and chimeras in 8q24 between Groups A and B. c Correlation analysis between the number of genomic breakpoints and chimeras in the 8q24 region identified by CS (left) and FM (right)