Fig. 2.

Pro-apoptotic proteins and signaling molecules in KAN0439834 treated cells. a CLL cells incubated with KAN0439834 (25–500 nM) (24 h) showed downregulation of BCL-2, Bcl-xl, MCL-1, and BAX, as well as cleaved PARP and caspase 1 and 3 [(one representative experiment out of three (WB)]; b CLL cells incubated with KAN0439834 (25–500 nM) (2 h) and tested for total and phosphorylated ROR1, LRP6, SRC, GSK-3β, AKT, PI3Kδ, mTOR, MAPK, JNK, CREB, c-JUN, β-catenin (one representative out of three-experiments)