Table I.

Markers of iron metabolism and erythropoiesis in patients with erythrocytosis

	Age	Hb	MCV	EPO	sTfR1	Fe	Tf sat	Ferritin	Hepcidin	ERFE
Units	Years	g/dL	fL	U/L	nmol/L	ug/mL	%	ng/mL	ng/mL	ng/mL
Normal ranges		13-17	80-96	4.1-19.5	0.9–2.3	65-180	20-50	12-300	29-254	12 ± 9a
JAK2 WT	57 ± 13	18 ± 1	90 ± 6	10 ± 4	4 ± 1	24 ± 13	34 ± 20	204 ± 180	78 ± 33	7 ± 4
JAK2 MUT	73 ± 11	19 ± 2	85 ± 8	3 ± 3	8 ± 6	12 ± 6	18 ± 11	70 ± 102	45 ± 35	24 ± 19
P value	0.0002	0.22	0.02	< 0.0001	0.005	0.001	0.006	0.01	0.006	0.0003

Hb hemoglobin, MCV mean corpuscular volume, EPO serum erythropoietin, sTfR1 soluble transferrin receptor 1, Fe serum iron, Tf sat transferrin saturation, ERFE serum erythroferrone, JAK2 WT wild type JAK2, JAK2 MUT mutant JAK2 (V617F or exon 12)

^aAdapted from ref. [88]