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. 2018 Oct 3;8:14752. doi: 10.1038/s41598-018-33018-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MA can colonize Apoe^−/− mice guts and lower their plasma TMAO concentrations. (A) Q-PCR analysis of fecal samples from Apoe^−/− mice transplanted with one of the 3 different MA, namely: M. smithii, M. mazei, and M. blatticola. Stool samples were collected at days 2, 10, and 30 post-transplantation. (B) Plasma TMAO concentrations in mock- and MA-transplanted Apoe^−/− mice collected at days 2, 10 and 30 post-transplantation. Mock-transplanted negative control mice (NC) only received regular water, whereas mock-transplanted positive control mice (PC) received high choline/TMA water, similar to MA-transplanted mice.