Fig. 2.

Interactions between NDUFA4 and other subunits of CIV. a Charge-smoothed potential map of CIV generated by PyMOL, except that NDUFA4 is shown in cartoon. Shown in two differently rotated views along the mitochondrial inner membrane. CDL and PEE are shown in stick and colored yellow and blue, respectively. The N- and C-terminals are indicated. b Cryo-EM densities of the NDUFA4 in human CIV monomer, superimposed with atomic model. The N and C terminals are indicated. c Interactions between NDUFA4 and other subunits of CIV. Residues and subunits are labeled and shown in stick and cartoon, respectively. CDL is colored yellow and labeled red. d NDUFA4 interact with the cardiolipin molecule in CIV monomer. Cardiolipin is shown in yellow sticks. Residues and subunits directly involved in cardiolipin binding are labeled and shown in stick and cartoon, respectively. Hydrogen bonds are shown in dashed lines