Fig. 5.

Three different subunits in human CIV. a Cryo-EM densities of three different subunits in human CIV monomer, superimposed with respective atomic models. The N- and C-terminals are indicated. b Position of three different subunits of CIV in supercomplex I₁III₂IV₁. Protein complexes and subunits are in the same colors with the corresponding labels, respectively. Proteins are shown in cartoon and the cofactors are shown in spheres. c Top view from the matrix side of the position of three different subunits of CIV in supercomplex I₁III₂IV₁. d Position of COX6A1 and COX7A2 in supercomplex I₁III₂IV₁. View from CIII and CIV side of supercomplex I₁III₂IV₁. e Position of COX8A and COX7A2 in supercomplex I₁III₂IV₁. View from CI and CIV side of supercomplex I₁III₂IV₁. c–e are shown in the same way as in (b)