Table 1.
Prognostic factor | Points | |
---|---|---|
Del17p on FISH or TP53 mutation | 4 | |
Unmutated IGHV genes | 2 | |
Serum β2 microglobulin >3.5 mg/L | 2 | |
Rai stage I–IV | 1 | |
Age >65 years | 1 |
Cumulative CLL-IPI score | Risk category | 5-year TFSa |
---|---|---|
0–1 | Low risk | 78% |
2–3 | Intermediate risk | 54% |
4–6 | High risk | 32% |
7–10 | Very high risk | 0% |
FISH fluorescence in situ hybridization, IGHV immunoglobulin heavy chain gene, TFS treatment-free survival
aFor the Mayo validation cohort