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. 2018 Oct 3;8:14723. doi: 10.1038/s41598-018-33082-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Progenitor/stem cell therapy restores foot process effacement. (A) Foot process width (FPW) was not different between saline and c-kit treated groups at day 10. (B) Representative images of the transmission electron microscopy (TEM) for saline and c-kit treated animals at day 10 (n = 4 in each group). (C) FPW was lower in the c-kit (a, *P = 0.03) and MSC (b, *P = 0.047) treated groups when compared to the saline group at day 21 (n = 4 in each group). FPW was higher in the saline, c-kit and MSC-treated groups when compared to normal kidneys (c,d,e; all ****P < 0.0001, respectively). (D) Representative images of the transmission electron microscopy (TEM) for saline, c-kit, and MSC-treated animals at day 21 (n = 4 in each group) and normal kidney (NK, n = 3). All data are means ± SEM. Scale bars represent 2 μm for (B) and 1 μm for (D).