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. 2018 Oct 3;8:14724. doi: 10.1038/s41598-018-33037-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Vegfr2 heterozygosity impairs Lewis lung carcinoma (LLM) tumor growth, angiogenesis, and VEGFR2 phosphorylation. (a) LLC tumor volume 20 days post tumor cell inoculation showing a significant decrease in Vegfr2^Cre/+ compared to control wild type mice (n = 5–6). (b,c) Immunofluorescent staining (b) and quantitation (c) of CD31-positive tumor vasculature and phospho-VEGFR2 (yellow arrows) showing a significant decrease in Vegfr2^Cre/+ compared to control mouse (n = 5–6). Two-way repeated-measures ANOVA with Sidak’s multiple comparism-test (a) and two-tailed Student’s t-test (c) were used to analyze significance (*p < 0.05; ***p < 0.001) compared to control.