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. 2018 Oct 3;8:14724. doi: 10.1038/s41598-018-33037-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A model depicting Vegfr2 heterozygosity effect on tumor growth and accompanying angiogenesis. (a) Mice containing wild type (wt) alleles of Vegfr2 and Fgfr1/2 develop tumors in a skin carcinogenesis or transplantation model. (b) Loss of Vegfr2 in hematopoietic cells does not affect tumorigenesis. (c) Vegfr2 heterozygosity (in endothelial cells and hematopoietic cells) impairs tumor growth and angiogenesis. Additional loss of endothelial Fgfr1 and Fgfr2 does not further impair tumor growth or angiogenesis in Vegfr2 heterozygous mice.