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. 2018 Oct 3;8:14760. doi: 10.1038/s41598-018-33034-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histogram of total voxel frequency of parameter estimates on K₁, k₂, k₃, k₄ and V_B (from top to bottom) from fits with the 2TCM in grade III tumors (left column) and grade IV tumors (right column), respectively. A clear shift towards higher values for grade IV tumors can be seen for K₁ and k₂, and to some extend for V_B and k₃. Distributions for k₄ are relatively similar.