Figure 2.

Substrate Scope Investigation

(A) C-C insertion reaction of N-nosylhydrazones.

(B) C-C insertion reaction of 1,3-dicarbonyls.

(C) Diastereoselective insertion into α-substituted 1,3-dicarbonyls.

Reaction conditions: N-nosylhydrazones (0.3 mmol), NaH (0.45 mmol), and CH₂Cl₂ (6.0 mL) were stirred at room temperature for 1 hr, then 1,3-dicarbonyls (0.45 mmol) and AgOTf (0.03 mmol) were added, after which the mixture was stirred at 40°C for 18 hr; yields are isolated yields. The reaction was performed at 50°C for compounds 20–27. PCP, p-chlorophenyl for compounds 28–46. See also Figures S3–S111.