Figure 6.
CTLA4 subcellular distribution transiently changes upon variation of CTLA4 synthesis. The rate of protein synthesis (σi) is varied (A) sharply and (B) smoothly from its original value, and the dynamic change of the fraction of CTLA4 molecules expressed on the cell surface (Rp(t)/(Rp(t) + Rc(t))) is calculated. After a transient change, the fraction converges to its original (steady-state) value (kr + δc)/(ki + kr + δc). Deviation (%) of the fraction from its steady-state value is shown. To see this figure in color, go online.