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. 2018 Sep 27;9:2091. doi: 10.3389/fimmu.2018.02091

Figure 6.

Figure 6

PPI did not affect CD40 and CD86 expression triggered by LPS/IFN-γ, which does not require NFκB activation. (A, B) CD40 and CD86 mRNA expression of BMMs was pretreated with PPI (0.25, 0.5, or 1 μM) or the same volume DMSO for 3 h, then stimulated with LPS (1 μg/ml) /IFN-γ (100 ng/ml) for another 6 h. Data represent mean ± SEM. NS, P > 0.05, one-way ANOVA. (C–G) BMMs or PEMs were pretreated with PPI (0.25, 0.5, or 1 μM) or the same volume DMSO for 3 h, then treated with LPS (1μg/ml)/IFN-γ (100ng/ml) for another 24 h, CD86 level were examined by flow cytometry. Data represent mean ± SEM. NS, P > 0.05, *P < 0.05, one-way ANOVA.