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. 2018 Sep 27;9:2091. doi: 10.3389/fimmu.2018.02091

Figure 9.

Figure 9

PPI did not show any damage effect on liver and kidney of CIA and normal mice. (A) The hematoxylin-eosin (H&E) staining of kidney and liver of CIA mice treated by CMC-Na with or without PPI (4×). (B, C) Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). (D) The ratio of ALT/AST. (E, F) Serum creatinine (CRE) and blood urea nitrogen (UREA) were detected by CRE reagent kit or UREA reagent kit. (B–F) Data represent mean ± SEM of two pooled experiments, n = 4 for Mock, n = 7 for Model+CMC-Na and n = 6 for Model+PPI group. NS, P > 0.05, one-way ANOVA. (G) H&E staining of the kidney and liver of normal mice treated with CMC-Na with or without PPI for 7 weeks (4×). (H–L) Serum level of AST, ALT, ALT/AST, UREA, and CRE of normal mice treated by CMC-Na with or without PPI. Data represent mean ± SEM of one pooled experiments. n = 5 for the CMC-Na and n = 5 for the PPI group, NS, P > 0.05, *P < 0.05, Student's t-test.