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. 2018 Sep 27;9:1092. doi: 10.3389/fphar.2018.01092

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Copyright © 2018 Zheng, Lin, Lin, Lin, Thapa, Lin, Lian, Liu, Chen and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transfection H9C2 with AMPKα siRNA reversed the suppression of NF-kB p65 and pro-inflammatory cytokines by SH post-hypoxia. (A) The expression of AMPK of H9C2 transfected with AMPKα siRNA. Control, n = 6; non-target siRNA, n = 6; AMPKα siRNA, n = 6. NS indicated p > 0.05, ^∗indicated p < 0.05. (B) The expression of NF-kB p65, IL-6 and TNFα of H9C2 transfected with AMPKα siRNA. CoCl₂, n = 6; CoCl₂+SH, n = 6; CoCl₂+SH+AMPKα siRNA, n = 6. ^∗Indicated p < 0.05; ^Δcompared with CoCl₂ group, p < 0.05; ^#compared with CoCl₂+SH group, p < 0.05.